AustralieFrV1, Main, Exploration, bibRecord, 002A26

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.

Identifieur interne : 002A26 ( Main/Exploration ); précédent : 002A25; suivant : 002A27

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.

Auteurs : Antoni Ribas [États-Unis] ; Igor Puzanov [États-Unis] ; Reinhard Dummer [Suisse] ; Dirk Schadendorf [Allemagne] ; Omid Hamid [États-Unis] ; Caroline Robert [France] ; F Stephen Hodi [États-Unis] ; Jacob Schachter [Israël] ; Anna C. Pavlick [États-Unis] ; Karl D. Lewis [États-Unis] ; Lee D. Cranmer [États-Unis] ; Christian U. Blank [Pays-Bas] ; Steven J. O'Day [États-Unis] ; Paolo A. Ascierto [Italie] ; April K S. Salama [États-Unis] ; Kim A. Margolin [États-Unis] ; Carmen Loquai [Allemagne] ; Thomas K. Eigentler [Allemagne] ; Tara C. Gangadhar [États-Unis] ; Matteo S. Carlino [Australie] ; Sanjiv S. Agarwala [États-Unis] ; Stergios J. Moschos [États-Unis] ; Jeffrey A. Sosman [États-Unis] ; Simone M. Goldinger [Suisse] ; Ronnie Shapira-Frommer [Israël] ; Rene Gonzalez [États-Unis] ; John M. Kirkwood [États-Unis] ; Jedd D. Wolchok [États-Unis] ; Alexander Eggermont [France] ; Xiaoyun Nicole Li [États-Unis] ; Wei Zhou [États-Unis] ; Adriane M. Zernhelt [États-Unis] ; Joy Lis [États-Unis] ; Scot Ebbinghaus [États-Unis] ; S Peter Kang [États-Unis] ; Adil Daud [États-Unis]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2015.

RBID : pubmed:26115796

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de l'intention de traiter, Anticorps monoclonaux (usage thérapeutique), Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (usage thérapeutique), Antinéoplasiques (administration et posologie), Antinéoplasiques (effets indésirables), Antinéoplasiques (usage thérapeutique), Estimation de Kaplan-Meier, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Mélanome (anatomopathologie), Mélanome (immunologie), Mélanome (mortalité), Mélanome (traitement médicamenteux), Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Résistance aux médicaments antinéoplasiques, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs cutanées (anatomopathologie), Tumeurs cutanées (immunologie), Tumeurs cutanées (mortalité), Tumeurs cutanées (traitement médicamenteux), Évolution de la maladie.
MESH :
- administration et posologie : Anticorps monoclonaux humanisés, Antinéoplasiques.
- anatomopathologie : Mélanome, Tumeurs cutanées.
- effets indésirables : Anticorps monoclonaux humanisés, Antinéoplasiques, Protocoles de polychimiothérapie antinéoplasique.
- immunologie : Mélanome, Tumeurs cutanées.
- mortalité : Mélanome, Tumeurs cutanées.
- traitement médicamenteux : Mélanome, Tumeurs cutanées.
- usage thérapeutique : Anticorps monoclonaux, Anticorps monoclonaux humanisés, Antinéoplasiques, Protocoles de polychimiothérapie antinéoplasique.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de l'intention de traiter, Estimation de Kaplan-Meier, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Résistance aux médicaments antinéoplasiques, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Évolution de la maladie.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal (therapeutic use), Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Antineoplastic Agents (administration & dosage), Antineoplastic Agents (adverse effects), Antineoplastic Agents (therapeutic use), Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Disease Progression, Disease-Free Survival, Drug Resistance, Neoplasm, Female, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, Male, Melanoma (drug therapy), Melanoma (immunology), Melanoma (mortality), Melanoma (pathology), Middle Aged, Skin Neoplasms (drug therapy), Skin Neoplasms (immunology), Skin Neoplasms (mortality), Skin Neoplasms (pathology), Time Factors, Treatment Outcome, Young Adult.
MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antineoplastic Agents.
- chemical , adverse effects : Antibodies, Monoclonal, Humanized, Antineoplastic Agents.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols.
- drug therapy : Melanoma, Skin Neoplasms.
- immunology : Melanoma, Skin Neoplasms.
- mortality : Melanoma, Skin Neoplasms.
- pathology : Melanoma, Skin Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adolescent, Adult, Aged, Aged, 80 and over, Disease Progression, Disease-Free Survival, Drug Resistance, Neoplasm, Female, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, Male, Middle Aged, Time Factors, Treatment Outcome, Young Adult.

Abstract

Patients with melanoma that progresses on ipilimumab and, if BRAF(V600) mutant-positive, a BRAF or MEK inhibitor or both, have few treatment options. We assessed the efficacy and safety of two pembrolizumab doses versus investigator-choice chemotherapy in patients with ipilimumab-refractory melanoma.

DOI: 10.1016/S1470-2045(15)00083-2
PubMed: 26115796

Affiliations:

Le document en format XML

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<affiliation wicri:level="3"><nlm:affiliation>Universitätsklinikum Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Universitätsklinikum Tübingen, Tübingen</wicri:regionArea>
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<author><name sortKey="Gangadhar, Tara C" sort="Gangadhar, Tara C" uniqKey="Gangadhar T" first="Tara C" last="Gangadhar">Tara C. Gangadhar</name>
<affiliation wicri:level="2"><nlm:affiliation>Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carlino, Matteo S" sort="Carlino, Matteo S" uniqKey="Carlino M" first="Matteo S" last="Carlino">Matteo S. Carlino</name>
<affiliation wicri:level="1"><nlm:affiliation>Crown Princess Mary Cancer Centre, Westmead and Blacktown Hospitals, and Melanoma Institute Australia, Westmead, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Crown Princess Mary Cancer Centre, Westmead and Blacktown Hospitals, and Melanoma Institute Australia, Westmead, NSW</wicri:regionArea>
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<author><name sortKey="Agarwala, Sanjiv S" sort="Agarwala, Sanjiv S" uniqKey="Agarwala S" first="Sanjiv S" last="Agarwala">Sanjiv S. Agarwala</name>
<affiliation wicri:level="2"><nlm:affiliation>St Luke's Cancer Center, Bethlehem, PA, USA; Temple University, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St Luke's Cancer Center, Bethlehem, PA, USA; Temple University, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moschos, Stergios J" sort="Moschos, Stergios J" uniqKey="Moschos S" first="Stergios J" last="Moschos">Stergios J. Moschos</name>
<affiliation wicri:level="2"><nlm:affiliation>University of North Carolina, Chapel Hill, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of North Carolina, Chapel Hill, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sosman, Jeffrey A" sort="Sosman, Jeffrey A" uniqKey="Sosman J" first="Jeffrey A" last="Sosman">Jeffrey A. Sosman</name>
<affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Cancer Center, Nashville, TN</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goldinger, Simone M" sort="Goldinger, Simone M" uniqKey="Goldinger S" first="Simone M" last="Goldinger">Simone M. Goldinger</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Zürich, Zürich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>University of Zürich, Zürich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
<settlement type="city">Zurich</settlement>
</placeName>
<orgName type="university">Université de Zurich</orgName>
</affiliation>
</author>
<author><name sortKey="Shapira Frommer, Ronnie" sort="Shapira Frommer, Ronnie" uniqKey="Shapira Frommer R" first="Ronnie" last="Shapira-Frommer">Ronnie Shapira-Frommer</name>
<affiliation wicri:level="1"><nlm:affiliation>Sheba Medical Center, Tel Hashomer, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sheba Medical Center, Tel Hashomer</wicri:regionArea>
<wicri:noRegion>Tel Hashomer</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Rene" sort="Gonzalez, Rene" uniqKey="Gonzalez R" first="Rene" last="Gonzalez">Rene Gonzalez</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Colorado Denver, Aurora, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Colorado Denver, Aurora, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirkwood, John M" sort="Kirkwood, John M" uniqKey="Kirkwood J" first="John M" last="Kirkwood">John M. Kirkwood</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Wolchok, Jedd D" sort="Wolchok, Jedd D" uniqKey="Wolchok J" first="Jedd D" last="Wolchok">Jedd D. Wolchok</name>
<affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eggermont, Alexander" sort="Eggermont, Alexander" uniqKey="Eggermont A" first="Alexander" last="Eggermont">Alexander Eggermont</name>
<affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy and Paris-Sud University, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Gustave Roussy and Paris-Sud University, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Xiaoyun Nicole" sort="Li, Xiaoyun Nicole" uniqKey="Li X" first="Xiaoyun Nicole" last="Li">Xiaoyun Nicole Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zernhelt, Adriane M" sort="Zernhelt, Adriane M" uniqKey="Zernhelt A" first="Adriane M" last="Zernhelt">Adriane M. Zernhelt</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lis, Joy" sort="Lis, Joy" uniqKey="Lis J" first="Joy" last="Lis">Joy Lis</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ebbinghaus, Scot" sort="Ebbinghaus, Scot" uniqKey="Ebbinghaus S" first="Scot" last="Ebbinghaus">Scot Ebbinghaus</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, S Peter" sort="Kang, S Peter" uniqKey="Kang S" first="S Peter" last="Kang">S Peter Kang</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
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</author>
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<author><name sortKey="Hamid, Omid" sort="Hamid, Omid" uniqKey="Hamid O" first="Omid" last="Hamid">Omid Hamid</name>
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<wicri:regionArea>The Angeles Clinic and Research Institute, Los Angeles, CA</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name>
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<wicri:regionArea>Gustave Roussy and Paris-Sud University, Villejuif</wicri:regionArea>
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</author>
<author><name sortKey="Hodi, F Stephen" sort="Hodi, F Stephen" uniqKey="Hodi F" first="F Stephen" last="Hodi">F Stephen Hodi</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author><name sortKey="Schachter, Jacob" sort="Schachter, Jacob" uniqKey="Schachter J" first="Jacob" last="Schachter">Jacob Schachter</name>
<affiliation wicri:level="1"><nlm:affiliation>Sheba Medical Center, Tel Hashomer, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sheba Medical Center, Tel Hashomer</wicri:regionArea>
<wicri:noRegion>Tel Hashomer</wicri:noRegion>
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</author>
<author><name sortKey="Pavlick, Anna C" sort="Pavlick, Anna C" uniqKey="Pavlick A" first="Anna C" last="Pavlick">Anna C. Pavlick</name>
<affiliation wicri:level="2"><nlm:affiliation>New York University Cancer Institute, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>New York University Cancer Institute, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lewis, Karl D" sort="Lewis, Karl D" uniqKey="Lewis K" first="Karl D" last="Lewis">Karl D. Lewis</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Colorado Denver, Aurora, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Colorado Denver, Aurora, CO</wicri:regionArea>
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</placeName>
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<author><name sortKey="Cranmer, Lee D" sort="Cranmer, Lee D" uniqKey="Cranmer L" first="Lee D" last="Cranmer">Lee D. Cranmer</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Arizona Cancer Center, Tucson, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Arizona Cancer Center, Tucson, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
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<author><name sortKey="Blank, Christian U" sort="Blank, Christian U" uniqKey="Blank C" first="Christian U" last="Blank">Christian U. Blank</name>
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<author><name sortKey="O Day, Steven J" sort="O Day, Steven J" uniqKey="O Day S" first="Steven J" last="O'Day">Steven J. O'Day</name>
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<author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto Nazionale Tumori Fondazione G. Pascale, Napoli</wicri:regionArea>
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</author>
<author><name sortKey="Salama, April K S" sort="Salama, April K S" uniqKey="Salama A" first="April K S" last="Salama">April K S. Salama</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke Cancer Institute, Durham, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Duke Cancer Institute, Durham, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Margolin, Kim A" sort="Margolin, Kim A" uniqKey="Margolin K" first="Kim A" last="Margolin">Kim A. Margolin</name>
<affiliation wicri:level="4"><nlm:affiliation>Seattle Cancer Care Alliance/University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Washington (État)</region>
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<author><name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center, Mainz</wicri:regionArea>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Eigentler, Thomas K" sort="Eigentler, Thomas K" uniqKey="Eigentler T" first="Thomas K" last="Eigentler">Thomas K. Eigentler</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Gangadhar, Tara C" sort="Gangadhar, Tara C" uniqKey="Gangadhar T" first="Tara C" last="Gangadhar">Tara C. Gangadhar</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
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<author><name sortKey="Carlino, Matteo S" sort="Carlino, Matteo S" uniqKey="Carlino M" first="Matteo S" last="Carlino">Matteo S. Carlino</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
</author>
<author><name sortKey="Agarwala, Sanjiv S" sort="Agarwala, Sanjiv S" uniqKey="Agarwala S" first="Sanjiv S" last="Agarwala">Sanjiv S. Agarwala</name>
<affiliation wicri:level="2"><nlm:affiliation>St Luke's Cancer Center, Bethlehem, PA, USA; Temple University, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St Luke's Cancer Center, Bethlehem, PA, USA; Temple University, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moschos, Stergios J" sort="Moschos, Stergios J" uniqKey="Moschos S" first="Stergios J" last="Moschos">Stergios J. Moschos</name>
<affiliation wicri:level="2"><nlm:affiliation>University of North Carolina, Chapel Hill, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of North Carolina, Chapel Hill, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sosman, Jeffrey A" sort="Sosman, Jeffrey A" uniqKey="Sosman J" first="Jeffrey A" last="Sosman">Jeffrey A. Sosman</name>
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<wicri:regionArea>Vanderbilt-Ingram Cancer Center, Nashville, TN</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
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<author><name sortKey="Goldinger, Simone M" sort="Goldinger, Simone M" uniqKey="Goldinger S" first="Simone M" last="Goldinger">Simone M. Goldinger</name>
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<author><name sortKey="Shapira Frommer, Ronnie" sort="Shapira Frommer, Ronnie" uniqKey="Shapira Frommer R" first="Ronnie" last="Shapira-Frommer">Ronnie Shapira-Frommer</name>
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<country xml:lang="fr">Israël</country>
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<wicri:noRegion>Tel Hashomer</wicri:noRegion>
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<author><name sortKey="Gonzalez, Rene" sort="Gonzalez, Rene" uniqKey="Gonzalez R" first="Rene" last="Gonzalez">Rene Gonzalez</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Colorado Denver, Aurora, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Colorado Denver, Aurora, CO</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
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<author><name sortKey="Kirkwood, John M" sort="Kirkwood, John M" uniqKey="Kirkwood J" first="John M" last="Kirkwood">John M. Kirkwood</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
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<author><name sortKey="Wolchok, Jedd D" sort="Wolchok, Jedd D" uniqKey="Wolchok J" first="Jedd D" last="Wolchok">Jedd D. Wolchok</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Eggermont, Alexander" sort="Eggermont, Alexander" uniqKey="Eggermont A" first="Alexander" last="Eggermont">Alexander Eggermont</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Gustave Roussy and Paris-Sud University, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
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<author><name sortKey="Li, Xiaoyun Nicole" sort="Li, Xiaoyun Nicole" uniqKey="Li X" first="Xiaoyun Nicole" last="Li">Xiaoyun Nicole Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
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</author>
<author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Zernhelt, Adriane M" sort="Zernhelt, Adriane M" uniqKey="Zernhelt A" first="Adriane M" last="Zernhelt">Adriane M. Zernhelt</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lis, Joy" sort="Lis, Joy" uniqKey="Lis J" first="Joy" last="Lis">Joy Lis</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ebbinghaus, Scot" sort="Ebbinghaus, Scot" uniqKey="Ebbinghaus S" first="Scot" last="Ebbinghaus">Scot Ebbinghaus</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, S Peter" sort="Kang, S Peter" uniqKey="Kang S" first="S Peter" last="Kang">S Peter Kang</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daud, Adil" sort="Daud, Adil" uniqKey="Daud A" first="Adil" last="Daud">Adil Daud</name>
<affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Oncology</title>
<idno type="eISSN">1474-5488</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
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<term>Antineoplastic Agents (therapeutic use)</term>
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<term>Disease Progression</term>
<term>Disease-Free Survival</term>
<term>Drug Resistance, Neoplasm</term>
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<term>Humans</term>
<term>Intention to Treat Analysis</term>
<term>Kaplan-Meier Estimate</term>
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<term>Melanoma (drug therapy)</term>
<term>Melanoma (immunology)</term>
<term>Melanoma (mortality)</term>
<term>Melanoma (pathology)</term>
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<term>Skin Neoplasms (drug therapy)</term>
<term>Skin Neoplasms (immunology)</term>
<term>Skin Neoplasms (mortality)</term>
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<term>Mâle</term>
<term>Mélanome (anatomopathologie)</term>
<term>Mélanome (immunologie)</term>
<term>Mélanome (mortalité)</term>
<term>Mélanome (traitement médicamenteux)</term>
<term>Protocoles de polychimiothérapie antinéoplasique (effets indésirables)</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Tumeurs cutanées (anatomopathologie)</term>
<term>Tumeurs cutanées (immunologie)</term>
<term>Tumeurs cutanées (mortalité)</term>
<term>Tumeurs cutanées (traitement médicamenteux)</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Antineoplastic Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Antineoplastic Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Monoclonal, Humanized</term>
<term>Antineoplastic Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Antinéoplasiques</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Antinéoplasiques</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Mélanome</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Melanoma</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Melanoma</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Mélanome</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term>
<term>Anticorps monoclonaux humanisés</term>
<term>Antinéoplasiques</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Progression</term>
<term>Disease-Free Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Humans</term>
<term>Intention to Treat Analysis</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de l'intention de traiter</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with melanoma that progresses on ipilimumab and, if BRAF(V600) mutant-positive, a BRAF or MEK inhibitor or both, have few treatment options. We assessed the efficacy and safety of two pembrolizumab doses versus investigator-choice chemotherapy in patients with ipilimumab-refractory melanoma.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>Canton de Zurich</li>
<li>Caroline du Nord</li>
<li>Colorado</li>
<li>District de Tübingen</li>
<li>Hollande-Septentrionale</li>
<li>Massachusetts</li>
<li>New Jersey</li>
<li>Pennsylvanie</li>
<li>Rhénanie-Palatinat</li>
<li>Tennessee</li>
<li>Washington (État)</li>
<li>État de New York</li>
</region>
<settlement><li>Amsterdam</li>
<li>Mayence</li>
<li>Pittsburgh</li>
<li>Seattle</li>
<li>Tübingen</li>
<li>Zurich</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
<li>Université de Washington</li>
<li>Université de Zurich</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name>
</region>
<name sortKey="Agarwala, Sanjiv S" sort="Agarwala, Sanjiv S" uniqKey="Agarwala S" first="Sanjiv S" last="Agarwala">Sanjiv S. Agarwala</name>
<name sortKey="Cranmer, Lee D" sort="Cranmer, Lee D" uniqKey="Cranmer L" first="Lee D" last="Cranmer">Lee D. Cranmer</name>
<name sortKey="Daud, Adil" sort="Daud, Adil" uniqKey="Daud A" first="Adil" last="Daud">Adil Daud</name>
<name sortKey="Ebbinghaus, Scot" sort="Ebbinghaus, Scot" uniqKey="Ebbinghaus S" first="Scot" last="Ebbinghaus">Scot Ebbinghaus</name>
<name sortKey="Gangadhar, Tara C" sort="Gangadhar, Tara C" uniqKey="Gangadhar T" first="Tara C" last="Gangadhar">Tara C. Gangadhar</name>
<name sortKey="Gonzalez, Rene" sort="Gonzalez, Rene" uniqKey="Gonzalez R" first="Rene" last="Gonzalez">Rene Gonzalez</name>
<name sortKey="Hamid, Omid" sort="Hamid, Omid" uniqKey="Hamid O" first="Omid" last="Hamid">Omid Hamid</name>
<name sortKey="Hodi, F Stephen" sort="Hodi, F Stephen" uniqKey="Hodi F" first="F Stephen" last="Hodi">F Stephen Hodi</name>
<name sortKey="Kang, S Peter" sort="Kang, S Peter" uniqKey="Kang S" first="S Peter" last="Kang">S Peter Kang</name>
<name sortKey="Kirkwood, John M" sort="Kirkwood, John M" uniqKey="Kirkwood J" first="John M" last="Kirkwood">John M. Kirkwood</name>
<name sortKey="Lewis, Karl D" sort="Lewis, Karl D" uniqKey="Lewis K" first="Karl D" last="Lewis">Karl D. Lewis</name>
<name sortKey="Li, Xiaoyun Nicole" sort="Li, Xiaoyun Nicole" uniqKey="Li X" first="Xiaoyun Nicole" last="Li">Xiaoyun Nicole Li</name>
<name sortKey="Lis, Joy" sort="Lis, Joy" uniqKey="Lis J" first="Joy" last="Lis">Joy Lis</name>
<name sortKey="Margolin, Kim A" sort="Margolin, Kim A" uniqKey="Margolin K" first="Kim A" last="Margolin">Kim A. Margolin</name>
<name sortKey="Moschos, Stergios J" sort="Moschos, Stergios J" uniqKey="Moschos S" first="Stergios J" last="Moschos">Stergios J. Moschos</name>
<name sortKey="O Day, Steven J" sort="O Day, Steven J" uniqKey="O Day S" first="Steven J" last="O'Day">Steven J. O'Day</name>
<name sortKey="Pavlick, Anna C" sort="Pavlick, Anna C" uniqKey="Pavlick A" first="Anna C" last="Pavlick">Anna C. Pavlick</name>
<name sortKey="Puzanov, Igor" sort="Puzanov, Igor" uniqKey="Puzanov I" first="Igor" last="Puzanov">Igor Puzanov</name>
<name sortKey="Salama, April K S" sort="Salama, April K S" uniqKey="Salama A" first="April K S" last="Salama">April K S. Salama</name>
<name sortKey="Sosman, Jeffrey A" sort="Sosman, Jeffrey A" uniqKey="Sosman J" first="Jeffrey A" last="Sosman">Jeffrey A. Sosman</name>
<name sortKey="Wolchok, Jedd D" sort="Wolchok, Jedd D" uniqKey="Wolchok J" first="Jedd D" last="Wolchok">Jedd D. Wolchok</name>
<name sortKey="Zernhelt, Adriane M" sort="Zernhelt, Adriane M" uniqKey="Zernhelt A" first="Adriane M" last="Zernhelt">Adriane M. Zernhelt</name>
<name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name>
</country>
<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name>
</region>
<name sortKey="Goldinger, Simone M" sort="Goldinger, Simone M" uniqKey="Goldinger S" first="Simone M" last="Goldinger">Simone M. Goldinger</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name>
</noRegion>
<name sortKey="Eigentler, Thomas K" sort="Eigentler, Thomas K" uniqKey="Eigentler T" first="Thomas K" last="Eigentler">Thomas K. Eigentler</name>
<name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name>
</country>
<country name="France"><noRegion><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name>
</noRegion>
<name sortKey="Eggermont, Alexander" sort="Eggermont, Alexander" uniqKey="Eggermont A" first="Alexander" last="Eggermont">Alexander Eggermont</name>
</country>
<country name="Israël"><noRegion><name sortKey="Schachter, Jacob" sort="Schachter, Jacob" uniqKey="Schachter J" first="Jacob" last="Schachter">Jacob Schachter</name>
</noRegion>
<name sortKey="Shapira Frommer, Ronnie" sort="Shapira Frommer, Ronnie" uniqKey="Shapira Frommer R" first="Ronnie" last="Shapira-Frommer">Ronnie Shapira-Frommer</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Blank, Christian U" sort="Blank, Christian U" uniqKey="Blank C" first="Christian U" last="Blank">Christian U. Blank</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Carlino, Matteo S" sort="Carlino, Matteo S" uniqKey="Carlino M" first="Matteo S" last="Carlino">Matteo S. Carlino</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.

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